Epidemiological studies and clinical trials revealed that chronic consumption coffee is associated with the inhibition of several metabolic diseases as well as reduction in overall and cause-specific mortality. We show that both natural and decaffeinated brands of coffee similarly rapidly trigger autophagy in mice. One to 4 h after coffee consumption, we observed an increase in autophagic flux in all investigated organs (liver, muscle, heart) in vivo, as indicated by the increased lipidation of LC3B and the reduction of the abundance of the autophagic substrate sequestosome 1 (p62/SQSTM1). These changes were accompanied by the inhibition of the enzymatic activity of mammalian target of rapamycin complex 1 (mTORC1), leading to the reduced phosphorylation of p70S6K, as well as by the global deacetylation of cellular proteins detectable by immunoblot. Immunohistochemical analyses of transgenic mice expressing a GFP–LC3B fusion protein confirmed the coffee-induced relocation of LC3B to autophagosomes, as well as general protein deacetylation. Altogether, these results indicate that coffee triggers 2 phenomena that are also induced by nutrient depletion, namely a reduction of protein acetylation coupled to an increase in autophagy. We speculate that polyphenols contained in coffee promote health by stimulating autophagy.
Coffee drinking has some of the same beneficial health effects of calorie restriction in mice. If this is true for people too it could reduce the chances of acquiring the diseases of aging. I think I’ll go brew a cup right now.
Space News has an update on SpaceX’s lawsuit against the U.S. Air Force over the 36-core bulk buy from ULA:
Judge Susan Braden on July 24 directed the two sides to explore a third alternative: mediation.
In SpaceX vs. USAF lawsuit, judge denies ULA’s request for immediate dismissal and gives both SpaceX and the Air Force tasks and deadlines pursuant to a resolution by mediation.
Sierra Nevada Corporation’s Dream Chaser engineering test vehicle is towed across the ramp at NASA’s Dryden Flight Research Center in preparation for tow tests on a Dryden taxiway. The tow…
Sierra Nevada agrees to cooperate with Japan’s space agency on technology and potentially launches from Japan.
In 2006 the IAU “demoted” Pluto to dwarf-planet status, setting off an outcry of public disappointment, first among schoolchildren but later among all classes of astronomy enthusiasts, and even planetary scientists, who disagree with the IA…
Is Pluto a planet or not? Was its demotion to dwarf planet status based on flawed logic? Let’s have the main proponents of the two postions duke it out with the whole world watching.
China’s Yutu, or Jade Rabbit, moon rover is apparently still “alive” entering into its eighth “working day” – a period of time equal to roughly 14 Earth days. However, the overall health of the robotic rover is not good. Yutu suffered a mechanical control problem in late January. Its antenna and solar panels could not…
China is working on a sample return mission to the moon, to launch in 2017. This would be the first return of lunar material to Earth since the end of the Apollo program.
Scientists who study aging have been telling us for years that we can expect a loss of muscle mass as we get older. We’re simply destined to lose muscle fibers, especially type II fibers – the fast twitch ones (Deschenes, Iannuzzi-Sucich, Karakelides, Proctor, Short, Wilkes). We are told to expect…
Use it or lose it.